The best moveset for Liepard in the current competitive meta typically features the moves Fake Out, Protect, Encore, Taunt.
In the Pokémon Champions meta, Liepard can be countered by exploiting its weaknesses (bug 2x, fairy 2x, fighting 2x) and using effective check/counter teams.
The best item for Liepard is typically Focus Sash, based on high-level tournament and ladder stats.